Culture of Rat Primary Cortical Cells for Microelectrode Array (MEA) Recordings to Screen for Acute and Developmental Neurotoxicity

Culture of Rat Primary Cortical Cells for Microelectrode Array (MEA) Recordings to Screen for Acute and Developmental Neurotoxicity

Neurotoxicity testing of chemicals, drug candidates, and environmental pollutants still relies on extensive in vivo studies that are very costly, time-consuming, and ethically debated due to the large number of animals typically used. Currently, rat primary cortical cultures are widely used for in v...

Full description

Bibliographic Details
Main Authors: de Groot, A. (Author), Gerber, L.-S (Author), van Kleef, R.G.D.M (Author), van Melis, L.V.J (Author), Westerink, R.H.S (Author)
Format: Article
Language:English
Published: Blackwell Publishing Inc. 2021
Subjects:
acute, subchronic and chronic exposure
animal
animal cell
Animals
Article
brain cell culture
brain cortex
cell activity
cell culture
cell growth
Cells, Cultured
Cerebral Cortex
controlled study
developmental toxicity
exposure
in vitro study
microelectrode
microelectrode array (MEA)
Microelectrodes
nerve cell
nerve cell network
neuronal activity analysis
Neurons
neurotoxicity
neurotoxicity screening
Neurotoxicity Syndromes
nonhuman
rat
rat primary cortical cultures
Rats
recordings
toxicity and intoxication
toxicity testing
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items