Cap 1 Messenger RNA Synthesis with Co-transcriptional CleanCap® Analog by In Vitro Transcription

Cap 1 Messenger RNA Synthesis with Co-transcriptional CleanCap® Analog by In Vitro Transcription

Synthetic messenger RNA (mRNA)−based therapeutics are an increasingly popular approach to gene and cell therapies, genome engineering, enzyme replacement therapy, and now, during the global SARS-CoV-2 pandemic, vaccine development. mRNA for such purposes can be synthesized through an enzymatic in vi...

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Bibliographic Details
Main Authors: Cabral, C.R (Author), Escamilla-Powers, J.R (Author), Henderson, J.M (Author), Hill, E. (Author), Houston, M.E (Author), Ko, N. (Author), McReynolds, T. (Author), Smith, C. (Author), Ujita, A. (Author), Yousif-Rosales, S. (Author)
Format: Article
Language:English
Published: Blackwell Publishing Inc. 2021
Subjects:
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Article
cap 1
cap analog
capped RNA
CleanCap
controlled study
enzyme mechanism
gene expression
human
Humans
in vitro study
In Vitro Techniques
in vitro transcription
isolation and purification
messenger RNA
Protein Biosynthesis
protein synthesis
RNA analysis
RNA Cap Analogs
RNA capping
RNA purification
RNA stability
RNA Stability
RNA structure
RNA synthesis
RNA transcription
RNA, Messenger
synthesis
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