Dorsolateral prefrontal circuit effective connectivity mediates the relationship between white matter structure and PASAT-3 performance in multiple sclerosis

Dorsolateral prefrontal circuit effective connectivity mediates the relationship between white matter structure and PASAT-3 performance in multiple sclerosis

Three decades ago a series of parallel circuits were described involving the frontal cortex and deep grey matter structures, with putative roles in control of motor and oculomotor function, cognition, behaviour and emotion. The circuit comprising the dorsolateral prefrontal cortex, caudate, globus p...

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Bibliographic Details
Main Authors: Auer, D.P (Author), Constantinescu, C.S (Author), das Nair, R. (Author), Dineen, R.A (Author), Elsarraj, A. (Author), Evangelou, N. (Author), Meng, D. (Author), Morgan, P.S (Author), Welton, T. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
adult
Adult
Article
caudate nucleus
cognition
cognitive defect
cohort analysis
Cohort Studies
controlled study
diagnostic imaging
disease severity
dorsolateral prefrontal circuit
dorsolateral prefrontal cortex
Dorsolateral Prefrontal Cortex
effective connectivity
female
Female
functional connectivity
functional magnetic resonance imaging
functional neuroimaging
globus pallidus
human
Humans
left hemisphere
major clinical study
male
Male
mediation effect
middle aged
Middle Aged
multiple sclerosis
Multiple Sclerosis
nerve cell network
Nerve Net
neuroanatomy
neuropsychological test
Neuropsychological Tests
observational study
paced auditory serial addition test
pathophysiology
priority journal
Prospective Studies
prospective study
psychology
putamen
radial diffusivity
right hemisphere
supplementary motor area
thalamus
white matter
White Matter
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