Classification of multiple sclerosis based on patterns of CNS regional atrophy covariance

Classification of multiple sclerosis based on patterns of CNS regional atrophy covariance

There is evidence that multiple sclerosis (MS) pathology leads to distinct patterns of volume loss over time (VLOT) in different central nervous system (CNS) structures. We aimed to use such patterns to identify patient subgroups. MS patients of all classical disease phenotypes underwent annual clin...

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Bibliographic Details
Main Authors: Amann, M. (Author), Barro, C. (Author), Chakravarty, M.M (Author), Gaetano, L. (Author), Granziera, C. (Author), Kappos, L. (Author), Kuhle, J. (Author), Magon, S. (Author), Naegelin, Y. (Author), Papadopoulou, A. (Author), Parmar, K. (Author), Pezold, S. (Author), Sprenger, T. (Author), Tsagkas, C. (Author), Wuerfel, J. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
adult
Adult
aged
Aged
alpha1a interferon
Article
atrophy
Atrophy
azathioprine
biomarkers
blood analysis
body fluid
brain
Brain
brain cortex
central nervous system
classification
clinical assessment
clinical feature
clinical outcome
cohort analysis
controlled study
corpus striatum
covariance
demyelinating autoimmune diseases
diagnostic imaging
disease classification
disease duration
disease exacerbation
Disease Progression
female
Female
glatiramer
globus pallidus
gray matter
hierarchical clustering
human
human tissue
Humans
image processing
Image Processing, Computer-Assisted
lesion volume
Longitudinal Studies
longitudinal study
Magnetic Resonance Imaging
major clinical study
male
Male
middle aged
Middle Aged
mitoxantrone
MRI
multiple sclerosis
Multiple Sclerosis
nervous system parameters
neurodegeneration
neurofilament
neuroimaging
Neuroimaging
neurologic disease
nuclear magnetic resonance imaging
pathology
patient identification
phase 2 clinical trial (topic)
phase 3 clinical trial (topic)
phenotypic variation
principal component analysis
priority journal
relapse
serology
spinal cord
Spinal Cord
spinothalamic tract
striate cortex
thalamus
volume loss over time
volumetry
white matter
young adult
Young Adult
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