The effect of risperidone on reward-related brain activity is robust to drug-induced vascular changes

Dopamine (DA) mediated brain activity is intimately linked to reward-driven cerebral responses, while aberrant reward processing has been implicated in several psychiatric disorders. fMRI has been a valuable tool in understanding the mechanism by which DA modulators alter reward-driven responses and...

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Bibliographic Details
Main Authors:	Dukart, J. (Author), Hawkins, P.C.T (Author), Holiga, S. (Author), Mehta, M.A (Author), O'Daly, O. (Author), Umbricht, D. (Author), Zelaya, F.O (Author)
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2021
Subjects:	adult Adult alertness amygdala anterior cingulate anticipation Anticipation, Psychological antipsychotic Article ASL blood vessel reactivity BOLD signal brain Brain brain blood flow brain circulation brain perfusion breath holding Breath Holding breath-hold caudate nucleus cerebrovascular Cerebrovascular Circulation controlled study crossover procedure Cross-Over Studies diagnostic imaging dopamine dopamine 2 receptor blocking agent Dopamine D2 Receptor Antagonists double blind procedure Double-Blind Method drug effect echo planar imaging electroencephalogram fMRI functional magnetic resonance imaging functional neuroimaging Functional Neuroimaging gray matter human human experiment Humans Magnetic Resonance Imaging male Male MID neurovascular coupling normal human nuclear magnetic resonance imaging outcome assessment placebo prefrontal cortex priority journal psychomotor performance Psychomotor Performance putamen randomized controlled trial reward Reward risperidone Risperidone task performance ventral striatum ventral tegmentum young adult Young Adult
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The effect of risperidone on reward-related brain activity is robust to drug-induced vascular changes

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