The interaction of child abuse and rs1360780 of the FKBP5 gene is associated with amygdala resting-state functional connectivity in young adults

The interaction of child abuse and rs1360780 of the FKBP5 gene is associated with amygdala resting-state functional connectivity in young adults

Extensive research has demonstrated that rs1360780, a common single nucleotide polymorphism within the FKBP5 gene, interacts with early-life stress in predicting psychopathology. Previous results suggest that carriers of the TT genotype of rs1360780 who were exposed to child abuse show differences i...

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Bibliographic Details
Main Authors: Artiges, E. (Author), Banaschewski, T. (Author), Barker, G.J (Author), Bokde, A.L.W (Author), Brühl, R. (Author), Daedelow, L.S (Author), Desrivières, S. (Author), Flor, H. (Author), Fröhner, J.H (Author), Garavan, H. (Author), Grigis, A. (Author), Heinz, A. (Author), Hohmann, S. (Author), IMAGEN Consortium (Author), Lett, T.A (Author), Martinot, J.-L (Author), Nees, F. (Author), Oei, N.Y.L (Author), Orfanos, D.P (Author), Poustka, L. (Author), Quinlan, E.B (Author), Schumann, G. (Author), Smolka, M.N (Author), Veer, I.M (Author), Walter, H. (Author), Wesarg, C. (Author), Whelan, R. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
adolescent
Adolescent
adult
Adult
Adult Survivors of Child Abuse
Adverse Childhood Experiences
amygdala
Amygdala
Article
brain region
child abuse
child abuse survivor
clinical trial
connectome
Connectome
diagnostic imaging
early life stress
emotional network
female
Female
fk 506 binding protein
FKBP5
fkbp5 protein
functional connectivity
functional magnetic resonance imaging
gene–environment interaction
Gene-Environment Interaction
genetics
genotype environment interaction
heterozygote
human
Humans
Magnetic Resonance Imaging
major clinical study
male
Male
mental disease
multicenter study
nuclear magnetic resonance imaging
phenotype
physiology
Polymorphism, Single Nucleotide
posterior insula
protein
resting-state functional connectivity
rs1360780
salience network
sensation
single nucleotide polymorphism
tacrolimus binding protein 5
Tacrolimus Binding Proteins
unclassified drug
young adult
Young Adult
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