The interaction of child abuse and rs1360780 of the FKBP5 gene is associated with amygdala resting-state functional connectivity in young adults

The interaction of child abuse and rs1360780 of the FKBP5 gene is associated with amygdala resting-state functional connectivity in young adults

Extensive research has demonstrated that rs1360780, a common single nucleotide polymorphism within the FKBP5 gene, interacts with early-life stress in predicting psychopathology. Previous results suggest that carriers of the TT genotype of rs1360780 who were exposed to child abuse show differences i...

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Bibliographic Details
Main Authors:	Artiges, E. (Author), Banaschewski, T. (Author), Barker, G.J (Author), Bokde, A.L.W (Author), Brühl, R. (Author), Daedelow, L.S (Author), Desrivières, S. (Author), Flor, H. (Author), Fröhner, J.H (Author), Garavan, H. (Author), Grigis, A. (Author), Heinz, A. (Author), Hohmann, S. (Author), IMAGEN Consortium (Author), Lett, T.A (Author), Martinot, J.-L (Author), Nees, F. (Author), Oei, N.Y.L (Author), Orfanos, D.P (Author), Poustka, L. (Author), Quinlan, E.B (Author), Schumann, G. (Author), Smolka, M.N (Author), Veer, I.M (Author), Walter, H. (Author), Wesarg, C. (Author), Whelan, R. (Author)
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2021
Subjects:	adolescent Adolescent adult Adult Adult Survivors of Child Abuse Adverse Childhood Experiences amygdala Amygdala Article brain region child abuse child abuse survivor clinical trial connectome Connectome diagnostic imaging early life stress emotional network female Female fk 506 binding protein FKBP5 fkbp5 protein functional connectivity functional magnetic resonance imaging gene–environment interaction Gene-Environment Interaction genetics genotype environment interaction heterozygote human Humans Magnetic Resonance Imaging major clinical study male Male mental disease multicenter study nuclear magnetic resonance imaging phenotype physiology Polymorphism, Single Nucleotide posterior insula protein resting-state functional connectivity rs1360780 salience network sensation single nucleotide polymorphism tacrolimus binding protein 5 Tacrolimus Binding Proteins unclassified drug young adult Young Adult
Online Access:	View Fulltext in Publisher

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