Ophthalmic changes in a spaceflight analog are associated with brain functional reorganization

Following long-duration spaceflight, some astronauts exhibit ophthalmic structural changes referred to as Spaceflight Associated Neuro-ocular Syndrome (SANS). Optic disc edema is a common sign of SANS. The origin and effects of SANS are not understood as signs of SANS have not manifested in previous...

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Bibliographic Details
Main Authors:	Beltran, N.E (Author), Bloomberg, J.J (Author), De Dios, Y.E (Author), Kofman, I.S (Author), Lee, J.K (Author), McGregor, H.R (Author), Mulavara, A.P (Author), Mulder, E.R (Author), Seidler, R.D (Author), Smith, S.M (Author), Zwart, S.R (Author)
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2021
Subjects:	adult Adult Article bed rest Bed Rest biochemical analysis brain cortex brain function brain region carbon dioxide Carbon Dioxide cerebellum Cerebellum Cerebral Cortex clinical article clinical assessment CO2 connectome Connectome controlled study cyanocobalamin diagnostic imaging electroencephalogram female Female frontal eye field functional connectivity functional magnetic resonance imaging genetic analysis head movement head-down tilt Head-Down Tilt homocysteine human Humans insula International Space Station Magnetic Resonance Imaging male Male middle aged Middle Aged middle frontal gyrus nerve cell network Nerve Net neuroimaging neurologic disease nuclear magnetic resonance imaging optic disc edema optic disk optic disk anomaly optical coherence tomography papilledema Papilledema pathophysiology physiology posterior cingulate posterior parietal cortex premotor cortex primary motor cortex putamen pyridoxine resting state network resting-state fMRI SANS space flight Space Flight spaceflight spaceflight associated neuroocular syndrome striate cortex vestibular function young adult Young Adult
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Ophthalmic changes in a spaceflight analog are associated with brain functional reorganization

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