A method to remove the influence of fixative concentration on postmortem T2 maps using a kinetic tensor model

A method to remove the influence of fixative concentration on postmortem T2 maps using a kinetic tensor model

Formalin fixation has been shown to substantially reduce T2 estimates, primarily driven by the presence of fixative in tissue. Prior to scanning, post-mortem samples are often placed into a fluid that has more favourable imaging properties. This study investigates whether there is evidence for a cha...

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Bibliographic Details
Main Authors: Ansorge, O. (Author), Foxley, S. (Author), Hurley, S.A (Author), Menke, R.A.L (Author), Miller, K.L (Author), Pallebage-Gamarallage, M. (Author), Qi, F. (Author), Tendler, B.C (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
7 T
amyotrophic lateral sclerosis
anisotropy
Article
autopsy
brain
Brain
brain tissue
concentration (parameter)
diagnosis
Diagnosis
diagnostic imaging
diffusion coefficient
diffusion MRI
diffusion tensor imaging
Diffusion Tensor Imaging
diffusion weighted imaging
electron spin resonance
ferritin
fixative
fixative modelling
Fixatives
formaldehyde
Formaldehyde
formalin
histology
human
Humans
model
Models, Theoretical
myelin and lymphocyte protein
pathology
post-mortem human brain
procedures
simulation
T2 mapping
T2 weighted imaging
theoretical model
tissue fixation
tissue preservation
Tissue Preservation
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