Azacitidine regulates DNA methylation of GADD45γ in myelodysplastic syndromes

Azacitidine regulates DNA methylation of GADD45γ in myelodysplastic syndromes

Background: Myelodysplastic syndrome (MDS) is a heterogeneous clonal disease originated from hematopoietic stem cells. Epigenetic studies had demonstrated that DNA methylation and histone acetylation were abnormal in MDS. Azacitidine is an effective drug in the treatment of demethylation. Methods: R...

Full description

Bibliographic Details
Main Authors: Geng, Y. (Author), Li, D. (Author), Li, J. (Author), Liu, L. (Author), Yang, Y. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
adult
apoptosis
Apoptosis
Article
azacitidine
Azacitidine
bisulfite sequencing
bone marrow cell
Bone Marrow Cells
caspase 3
caspase 7
caspase 9
cell cycle protein
Cell Cycle Proteins
cell line
Cell Line
cell proliferation
Cell Proliferation
chromatin assembly and disassembly
clinical article
colony formation
controlled study
cytogenetics
decitabine
dendritic cell
DNA methylation
DNA Methylation
drug effect
epigenetics
expression vector
female
GADD45A protein, human
GADD45γ
gene expression
Gene Expression
gene therapy
Genetic Therapy
genetic transfection
genetics
glyceraldehyde 3 phosphate dehydrogenase
growth arrest and DNA damage inducible protein 45
growth arrest and DNA damage inducible protein 45 gamma
hematologic disease
histone acetylation
HS-5 cell line
human
human cell
human tissue
Humans
male
MDS
middle aged
molecular genetics
myelodysplastic syndrome
Myelodysplastic Syndromes
overall survival
pathology
physiology
plasmid
polyacrylamide gel electrophoresis
polymerase chain reaction
procedures
prognosis
protein analysis
protein determination
protein expression
protein function
protein protein interaction
protein purification
real time polymerase chain reaction
RNA interference
RNA splicing
short hairpin RNA
SKM-1 cell line
survival rate
unclassified drug
Western blotting
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items