Overexpressed miR-335-5p reduces atherosclerotic vulnerable plaque formation in acute coronary syndrome

Background: Acute coronary syndrome (ACS) may induce cardiovascular death. The correlation of mast cells related microRNAs (miRs) with risk of ACS has been investigated. We explored regulatory mechanism of miR-335-5p on macrophage innate immune response, atherosclerotic vulnerable plaque formation,...

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Bibliographic Details
Main Authors:	Cui, B. (Author), Ma, T. (Author), Sun, D. (Author), Zhang, F. (Author), Zhang, Y. (Author)
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2021
Subjects:	24-diamino-5-phenylthiazole 3' untranslated region 3' Untranslated Regions acute coronary syndrome Acute Coronary Syndrome animal animal cell animal experiment animal model animal tissue Animals antagomir Antagomirs Article atherosclerotic plaque atherosclerotic vulnerable plaque blood C57BL mouse collagen Collagen collagen fiber controlled study coronary artery atherosclerosis diamine Diamines enzyme linked immunosorbent assay gene expression Gene Expression gene function gene overexpression genetic database genetic regulation genetics heart muscle revascularization human human cell Humans innate immune response of macrophage innate immunity intercellular adhesion molecule 1 interleukin 1beta interleukin 6 JAG1 JAG1 protein, human Jagged-1 Protein lipid lipid storage Lipids macrophage function male Male matrix metalloproteinase metabolism Mice, Inbred C57BL microarray analysis microRNA microRNA 335 5p microRNA-335-5p MicroRNAs MIRN335 microRNA, human Mirn335 microRNA, mouse monocyte chemotactic protein 1 mouse nonhuman Notch receptor notch signaling Notch signaling pathophysiology Plaque, Atherosclerotic protein expression protein Jagged 1 protein targeting real time reverse transcription polymerase chain reaction Receptors, Notch revascularization RNA analysis RNA interference thiazole derivative Thiazoles tissue inhibitor of metalloproteinase 1 tissue inhibitor of metalloproteinase 2 tumor necrosis factor unclassified drug vascular cell adhesion molecule 1 Western blotting
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Overexpressed miR-335-5p reduces atherosclerotic vulnerable plaque formation in acute coronary syndrome

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