The long non-coding RNA PCAL7 promotes prostate cancer by strengthening androgen receptor signaling

The long non-coding RNA PCAL7 promotes prostate cancer by strengthening androgen receptor signaling

Background: The prostate cancer (PCa) has been a global problem to men health. Notably, the androgen receptor (AR) is essential for both normal development of prostate and prostate cancer progression. Methods: The RNA sequencing was used to identify the novel long non-coding RNA (lncRNA) termed PCAL...

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Bibliographic Details
Main Authors: Ai, X. (Author), Jia, Z. (Author), Li, Z. (Author), Teng, J. (Author), Zhang, G. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
androgen receptor
antisense oligonucleotide
AR protein, human
Article
cancer growth
cancer tissue
carcinogenesis
Cell Line, Tumor
cell migration assay
cell motion
Cell Movement
cell proliferation
Cell Proliferation
cell proliferation assay
cellular distribution
controlled study
cytoplasm
Cytoplasm
DNA binding protein
DNA-Binding Proteins
down regulation
drug effect
fluorescence in situ hybridization
gene expression regulation
Gene Expression Regulation, Neoplastic
gene function
gene knockdown
gene overexpression
gene targeting
genetics
HIP1
HIP1 protein, human
human
human cell
human tissue
Humans
Huntingtin interacting protein 1
in vitro study
LNCaP cell line
LncRNA
long untranslated RNA
male
Male
membrane protein
metabolism
migration inhibition
Oligonucleotides, Antisense
pathology
PCAL7
prostate cancer
prostate cancer associated long noncoding RNA on chromosome 7
prostate tumor
Prostatic Neoplasms
protein RNA binding
protein stability
real time reverse transcription polymerase chain reaction
Receptors, Androgen
RNA analysis
RNA sequencing
RNA, Long Noncoding
signal transduction
Signal Transduction
tumor cell line
unclassified drug
upregulation
VcaP cell line
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