NAD(P)-dependent steroid dehydrogenase-like protein and neutral cholesterol ester hydrolase 1 serve as novel markers for early detection of gastric cancer identified using quantitative proteomics

NAD(P)-dependent steroid dehydrogenase-like protein and neutral cholesterol ester hydrolase 1 serve as novel markers for early detection of gastric cancer identified using quantitative proteomics

Background: Gastric cancer (GC) is the third most common cause of cancer deaths worldwide. In the present study, we aimed to identify novel GC biomarkers by integrating isobaric tags of relative and absolute quantitation (iTRAQ) for aberrantly expressed proteins in GC patients. Methods: Using stable...

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Bibliographic Details
Main Authors: Han, Q. (Author), Huang, W. (Author), Jiang, Z. (Author), Liu, L. (Author), Liu, S. (Author), Qin, J. (Author), Xiao, Y. (Author), Xie, J. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
3(or 17)beta hydroxysteroid dehydrogenase
3-Hydroxysteroid Dehydrogenases
adenocarcinoma
Adenocarcinoma
adult
aged
Aged
Article
Biomarkers, Tumor
cancer classification
cancer grading
cancer patient
cancer staging
Carcinoma, Signet Ring Cell
case control study
Case-Control Studies
cholesterol esterase
Cholesterol metabolism
controlled study
early cancer diagnosis
Early Detection of Cancer
early diagnosis
electrospray mass spectrometry
female
Female
Gastric cancer
histopathology
human
human tissue
Humans
immunohistochemistry
Immunohistochemistry
iTRAQ
iTRAQ labeling
liquid chromatography
lymph node metastasis
Lymphatic Metastasis
major clinical study
male
Male
metabolism
middle aged
Middle Aged
NCEH1
NCEH1 protein, human
neutral cholesterol ester hydrolase 1
nicotinamide adenine dinucleotide phosphate dependent steroid dehydrogenase like protein
NSDHL
Nsdhl protein, human
pathology
procedures
protein expression
proteomics
Proteomics
receiver operating characteristic
reproducibility
Reproducibility of Results
sensitivity and specificity
signet ring carcinoma
Spectrometry, Mass, Electrospray Ionization
stable isotope labeling
steroid reductase
Sterol Esterase
stomach adenocarcinoma
stomach cancer
Stomach Neoplasms
stomach tumor
tandem mass spectrometry
Tandem Mass Spectrometry
tumor invasion
tumor marker
unclassified drug
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