iTRAQ-based proteomic analysis of the molecular mechanisms and downstream effects of fatty acid synthase in osteosarcoma cells

iTRAQ-based proteomic analysis of the molecular mechanisms and downstream effects of fatty acid synthase in osteosarcoma cells

Background: Fatty acid synthase (FASN) is a lipogenic enzyme that participates in tumor progression. We previously showed that FASN is dysregulated in OS malignancy, but the molecular mechanism(s) of these effects remained unclear. Methods: We examined differentially expressed proteins (DEPs) in FAS...

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Bibliographic Details
Main Authors: Chen, W. (Author), Chen, X. (Author), Fu, D. (Author), Huang, S. (Author), Liu, J. (Author), Liu, S. (Author), Long, X. (Author), Zheng, Y. (Author), Zhou, Y. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
143B cell line
adult
Adult
Article
binding affinity
bioinformatics
Bone Neoplasms
bone tumor
cancer diagnosis
catalysis
cell invasion
cell invasion assay
Cell Line, Tumor
cell lysate
cell migration
cell motion
Cell Movement
cell proliferation
Cell Proliferation
colony formation
controlled study
down regulation
FASN
FASN protein, human
fatty acid synthase
Fatty Acid Synthase, Type I
female
Female
gene ontology
Gene Ontology
gene silencing
genetic database
genetic transfection
genetics
heterogeneous nuclear ribonucleoprotein A1
Heterogeneous Nuclear Ribonucleoprotein A1
HNRNPA1
hnRNPA1 protein, human
human
human cell
human tissue
Humans
immunohistochemistry
iTRAQ labeling
iTRAQ proteomic analysis
major clinical study
male
Male
metabolism
molecularly targeted therapy
osteosarcoma
Osteosarcoma
osteosarcoma cell
pathology
polymerase chain reaction
procedures
prognosis
protein analysis
protein expression
protein fingerprinting
protein function
protein protein interaction
proteomics
Proteomics
quantitative analysis
sequence analysis
signal transduction
tumor cell line
tumor marker
upregulation
validation process
Western blotting
wound healing
young adult
Young Adult
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