Development and validation of an LC-MS/MS method for quantifying nine antimicrobials in human serum and its application to study the exposure of Chinese pregnant women to antimicrobials

Development and validation of an LC-MS/MS method for quantifying nine antimicrobials in human serum and its application to study the exposure of Chinese pregnant women to antimicrobials

Background: To study the prevalence of the exposure of pregnant women to antimicrobials, a sensitive and reliable liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated to determine nine antimicrobials, namely sulfadimidine, sulfapyridine, sulfadiazine, sulfathi...

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Bibliographic Details
Main Authors: Cao, Z. (Author), Li, Y. (Author), Liu, Y. (Author), Pan, Z. (Author), Shen, M. (Author), Yue, X. (Author), Zhai, Y. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
adolescent
Adolescent
adult
Adult
antiinfective agent
Anti-Infective Agents
antimicrobials
Article
blood
blood analysis
blood sampling
calibration
Calibration
Chinese
Chinese pregnant women
Chromatography, Liquid
ciprofloxacin
controlled study
diagnostic test accuracy study
female
Female
human
Humans
LC-MS
limit of quantitation
lincomycin
liquid chromatography
liquid chromatography-mass spectrometry
MS
multiple reaction monitoring
norfloxacin
ofloxacin
perinatal drug exposure
precipitation
pregnancy
Pregnancy
pregnancy outcome
pregnant woman
prevalence
procedures
quality control
sensitivity and specificity
Sensitivity and Specificity
serum
solid phase extraction
sulfadiazine
sulfadimidine
sulfapyridine
sulfathiazole
tandem mass spectrometry
Tandem Mass Spectrometry
tetracycline
triple quadrupole mass spectrometry
young adult
Young Adult
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