Measurement of methotrexate in human cerebrospinal fluid using a chemiluminescence immunoassay intended for serum and plasma matrices

Measurement of methotrexate in human cerebrospinal fluid using a chemiluminescence immunoassay intended for serum and plasma matrices

Background: The concentration of MTX in blood is often measured quickly and easily by immunoassays. Thus, immunoassays may facilitate the easy determination of the concentration of MTX in the cerebrospinal fluid (CSF). In this study, we measured methotrexate (MTX) concentrations in the CSF using a h...

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Bibliographic Details
Main Authors: Hirabara, Y. (Author), Ikeda, R. (Author), Moritake, H. (Author), Yamada, A. (Author), Yokota, T. (Author), Yoshikawa, N. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
Article
Bland Altman plot
calibration
Calibration
cerebrospinal fluid
chemiluminescence immunoassay
Chromatography, High Pressure Liquid
confidence interval
controlled study
drug cerebrospinal fluid level
high performance liquid chromatography
high-performance liquid chromatography
human
Humans
immunoassay
Immunoassay
intermethod comparison
limit of detection
Limit of Detection
luminescence
Luminescent Measurements
methotrexate
Methotrexate
Passing Bablok regression
Passing-Bablok
plasma
procedures
regression analysis
reproducibility
Reproducibility of Results
serum
statistical analysis
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