The potential therapeutic role of PTR1 gene in non-healing anthroponotic cutaneous leishmaniasis due to Leishmania tropica

The potential therapeutic role of PTR1 gene in non-healing anthroponotic cutaneous leishmaniasis due to Leishmania tropica

Background: Drug resistance is a common phenomenon frequently observed in countries where leishmaniasis is endemic. Due to the production of the pteridine reductase enzyme (PTR1), drugs lose their efficacy, and consequently, the patient becomes unresponsive to treatment. This study aimed to compare...

Full description

Bibliographic Details
Main Authors: Bamorovat, M. (Author), Davoudi, N. (Author), Ghasemi Nejad Almani, P. (Author), Kazemi, B. (Author), Khosravi, A. (Author), Salari, S. (Author), Salarkia, E. (Author), Sezavar, M. (Author), Sharifi, I. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
adult
Adult
amastigote
animal
animal cell
Animals
antibiotic resistance
antiprotozoal agent
Antiprotozoal Agents
antisense
Article
Bagg albino mouse
case report
clinical article
complementary DNA
concentration response
cryotherapy
cutaneous leishmaniasis
DNA, Antisense
drug effect
drug efficacy
Drug Resistance, Microbial
drug response
electroporation
enzyme linked immunosorbent assay
female
Female
gene
genetic transfection
genetics
healing
human
Humans
IC50
in vitro study
isolation and purification
Leishmania
Leishmania tropica
Leishmaniasis, Cutaneous
liquid nitrogen
macrophage
male
Male
meglumine antimonate
Meglumine Antimoniate
Mice, Inbred BALB C
mouse
multiple cycle treatment
nonhuman
optical density
oxidoreductase
Oxidoreductases
parasite cultivation
parasite isolation
parasitology
pharmacology
polymerase chain reaction
promastigote
protozoal protein
Protozoan Proteins
pteridine reductase
PTR1 gene
resistance
systemic therapy
transfection
Transfection
treatment duration
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items