Selection and identification of an ssDNA aptamer to NB4 cell

Selection and identification of an ssDNA aptamer to NB4 cell

This study was to find the aptamers with high affinity and specificity binding to acute promyelocytic leukemia (APL) NB4 cell line. These aptamers targeted NB4 cells were selected from a random single-stranded DNA (ssDNA) library of systematic evolution of ligands by exponential enrichment (CELL-SEL...

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Bibliographic Details
Main Authors: Chen, X. (Author), Wang, W. (Author), Zhang, X.-H (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
APL
aptamer
Aptamers, Nucleotide
Article
binding affinity
Cell Line, Tumor
CELL-SELEX
chemistry
conformation
controlled study
DNA, Single-Stranded
flow cytometry
fluorescein isothiocyanate
fluorescence intensity
fluorescence microscopy
HL-60 cell line
human
Humans
K-562 cell line
kinetics
Kinetics
leukemia
metabolism
NB4 cell
NB4 cell line
Nucleic Acid Conformation
protein secondary structure
SELEX Aptamer Technique
sequence analysis
single stranded DNA
systematic evolution of ligands by exponential enrichment aptamer technique
tumor cell line
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