Serum exosomal microRNAs as predictive markers for EGFR mutations in non–small-cell lung cancer

Background: Current therapeutic drugs show positive effects on non–small-cell lung cancer (NSCLC) patients with mutant epidermal growth factor receptor (EGFR) expression, whereas a lesser beneficial effect is generally noted on NSCLC patients with wild-type EGFR. Therefore, identification of new det...

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Bibliographic Details
Main Authors:	Dai, L. (Author), Luo, M. (Author), Wang, L. (Author), Xia, J. (Author), Zhu, J. (Author)
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2021
Subjects:	adult aged Aged Article biology Biomarkers, Tumor blood blood sampling cancer patient cancer staging Carcinoma, Non-Small-Cell Lung Cell Line, Tumor Computational Biology controlled study down regulation early cancer EGFR EGFR gene EGFR protein, human epidermal growth factor receptor ErbB Receptors exosome Exosomes female Female gene expression gene mutation gene ontology Gene Ontology genetics human Humans Lung Neoplasms lung tumor major clinical study male Male microRNA microRNA 1116 microRNA 1169 microRNA 117 microRNA 1214 microRNA 1228 microRNA 1384 microRNA 15b 5p microRNA 260 microRNA 342 5p microRNA 403 microRNA 56 microRNA 604 microRNA 689 microRNA 72 microRNA 731 microRNA 818 microRNA 836 microRNA 898 microRNA 955 microRNA 99b 5p MicroRNAs middle aged Middle Aged miRNAs mutant mutation Mutation non invasive procedure non small cell lung cancer NSCLC prediction reproducibility Reproducibility of Results RNA sequencing tumor cell line tumor derived exosome tumor marker ultrastructure unclassified drug upregulation wild type
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Serum exosomal microRNAs as predictive markers for EGFR mutations in non–small-cell lung cancer

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