Mutational screening through comprehensive bioinformatics analysis to detect novel germline mutations in the APC gene in patients with familial adenomatous polyposis (FAP)

Background: Familial adenomatous polyposis (FAP) as a colon cancer predisposition syndrome is an autosomal-dominant inherited condition and is diagnosed by the progress of hundreds or thousands of adenomatous colonic polyps in the colon. This study aims at the nature and effect of Adenomatous Polypo...

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Bibliographic Details
Main Authors:	Bagherian, H. (Author), Ghadamyari, F. (Author), Ghasemi, F. (Author), Heidari, M.M (Author), Khatami, M. (Author), Merat, S. (Author), Rejali, L. (Author), Zeinali, S. (Author)
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2021
Subjects:	Adenomatous Polyposis Coli Adenomatous Polyposis Coli Protein adolescent Adolescent adult Adult amino acid substitution APC APC gene APC protein APC protein, human Article Base Sequence bioinformatics biology cancer carcinogenesis chemistry child Child Codon, Nonsense colon polyposis colonoscopy Colonoscopy Computational Biology diagnostic imaging dna mutational analysis DNA Mutational Analysis exon familial adenomatous polyposis female Female gene deletion gene function gene sequence genetic association Genetic Association Studies genetic association study genetic code genetic linkage Genetic Linkage genetic predisposition Genetic Predisposition to Disease genetic screening Genetic Testing genetic variability genetics genotype phenotype correlation germline mutation Germ-Line Mutation haplotype Haplotypes heterozygosity homozygosity human Humans Iranian (citizen) major clinical study male Male microsatellite marker missense mutation Models, Molecular molecular model multiplex polymerase chain reaction mutational analysis nonsense mutation nucleotide sequence pathogenicity pedigree Pedigree polymerase chain reaction prediction stop codon tumor-related gene young adult Young Adult
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Mutational screening through comprehensive bioinformatics analysis to detect novel germline mutations in the APC gene in patients with familial adenomatous polyposis (FAP)

Internet

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