PCR array analysis identified hyperproliferation but not autophagy or apoptosis in fibrous epulis

Background: The pathogenesis of fibrous epulis is still quite unclear. Our recent genome-wide RNA sequencing analysis revealed that in fibrous epulis, RAS-PI3K-AKT-NF-κB pathway regulates the expression of Bcl-2 family and IAP family genes, leading to increased proliferation and the inhibition of ap...

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Bibliographic Details
Main Authors:	Fang, B. (Author), Jiang, Y. (Author), Xu, B. (Author)
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2021
Subjects:	adult Adult apoptosis Apoptosis Article ATG family autophagy Autophagy autophagy (cellular) autophagy related protein Autophagy-Related Proteins Bcl-2 family BCL2 gene BCL2L1 gene BCL2L1 protein, human bcl-X Protein caspase caspase family Caspases cell proliferation Cell Proliferation controlled study CXCR4 gene female Female fibrous epulis gene gene expression gene expression profiling Gene Expression Profiling genetics gingiva Gingiva gingiva disease Gingival Diseases HSP90AA1 gene HSPA8 gene human human tissue Humans IGF1 gene major clinical study male Male middle aged Middle Aged pathogenesis pathology PCR array peptides and proteins physiology polymerase chain reaction Polymerase Chain Reaction procedures protein bcl 2 protein bcl x protein LC3 I protein LC3 II Proto-Oncogene Proteins c-bcl-2 unclassified drug
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PCR array analysis identified hyperproliferation but not autophagy or apoptosis in fibrous epulis

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