Association of alpha-thalassemia and Glucose-6-Phosphate Dehydrogenase deficiency with transcranial Doppler ultrasonography in Nigerian children with sickle cell anemia

Association of alpha-thalassemia and Glucose-6-Phosphate Dehydrogenase deficiency with transcranial Doppler ultrasonography in Nigerian children with sickle cell anemia

Background: Stroke is a devastating complication of sickle cell anemia (SCA) and can be predicted through abnormally high cerebral blood flow velocity using transcranial Doppler Ultrasonography (TCD). The evidence on the role of alpha-thalassemia and glucose-6-phosphate dehydrogenase (G6PD) deficien...

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Bibliographic Details
Main Authors: Adeyemo, T.A (Author), Benn, Y. (Author), Ekpo, M.G (Author), Iwalokun, B.A (Author), Ojewunmi, O.O (Author), Oyetunji, A.I (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
adolescent
Adolescent
alpha thalassemia
alpha-thalassemia
alpha-Thalassemia
Anemia, Sickle Cell
Article
blood flow velocity
Blood Flow Velocity
brain circulation
case control study
Case-Control Studies
cerebrovascular accident
Cerebrovascular Circulation
child
Child
Child, Preschool
complication
controlled study
diagnostic imaging
disease association
DNA polymorphism
female
Female
follow up
Follow-Up Studies
gene deletion
genetic variability
glucose 6 phosphate dehydrogenase
glucose 6 phosphate dehydrogenase deficiency
glucose 6 phosphate dehydrogenase gene
glucose-6-phosphate dehydrogenase deficiency
Glucosephosphate Dehydrogenase Deficiency
hemoglobin alpha chain
human
human cell
Humans
major clinical study
male
Male
morbidity
multiplex polymerase chain reaction
Nigeria
Nigerian
pathology
pathophysiology
polymerase chain reaction restriction fragment length polymorphism
preschool child
prognosis
Prognosis
risk factor
sickle cell anemia
stroke
Stroke
transcranial Doppler ultrasonography
Ultrasonography, Doppler, Transcranial
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