Targeted resequencing showing novel common and rare genetic variants increases the risk of asthma in the Chinese Han population

Targeted resequencing showing novel common and rare genetic variants increases the risk of asthma in the Chinese Han population

Background: Although studies have identified hundreds of genetic variants associated with asthma risk, a large fraction of heritability remains unexplained, especially in Chinese individuals. Methods: To identify genetic risk factors for asthma in a Han Chinese population, 211 asthma-related genes w...

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Bibliographic Details
Main Authors: Cheng, Z. (Author), Deng, Y. (Author), Fang, S. (Author), Li, J. (Author), Li, Z. (Author), Liu, J. (Author), Luo, G. (Author), Luo, L. (Author), Mo, B. (Author), Shu, Y. (Author), Wang, Y. (Author), Wang, Z. (Author), Wei, J. (Author), Xiong, W. (Author), Yang, H. (Author), Yang, J. (Author), Yu, B. (Author), Zhang, X. (Author), Zhu, J. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
adolescent
Adolescent
adult
Adult
aged
Aged
Aged, 80 and over
Article
asthma
Asthma
bioinformatics
biological marker
Biomarkers
case control study
Case-Control Studies
child
Child
Child, Preschool
China
cohort analysis
Cohort Studies
common variant
controlled study
female
Female
follow up
Follow-Up Studies
gene frequency
gene interaction
gene sequence
genetic predisposition
Genetic Predisposition to Disease
genetic risk
genetic selection
genetic variability
genetics
genome-wide association study
Genome-Wide Association Study
genotype
Han Chinese
high throughput sequencing
High-Throughput Nucleotide Sequencing
human
Humans
infant
Infant
Infant, Newborn
loss of function mutation
major clinical study
male
Male
metabolism
middle aged
Middle Aged
newborn
next-generation sequencing
pathology
Polymorphism, Single Nucleotide
population research
preschool child
procedures
prognosis
Prognosis
rare variant
risk factor
risk stratification
Sanger sequencing
single nucleotide polymorphism
very elderly
young adult
Young Adult
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