Age-stratified and gender-specific reference intervals of six tumor markers panel of lung cancer: A geographic-based multicenter study in China

Background: Serum biomarkers have been widely adopted in clinical practice for assisting lung cancer diagnoses, therapeutic monitoring, and prognostication. The function of a well-performing tumor biomarker depends on a reliable reference interval (RI) with consideration of the study subjects’ age,...

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Bibliographic Details
Main Authors:	Chen, Q. (Author), Chen, Y. (Author), Huang, H. (Author), Jiang, L. (Author), Li, G. (Author), Li, M. (Author), Li, X. (Author), Li, Y. (Author), liang Xing, J. (Author), Qu, W. (Author), Wang, S. (Author), Wang, W. (Author), Yang, C. (Author), Zhang, Y. (Author), Zhou, J. (Author)
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2021
Subjects:	adolescent Adolescent adult Adult age Age Factors aged antigen blood level antigen CYFRA21.1 Antigens, Neoplasm Article Biomarkers, Tumor blood blood sampling carcinoembryonic antigen Carcinoembryonic Antigen carrier protein Carrier Proteins CEACAM5 protein, human chemoluminescence China clinical laboratory standard clinical trial clinician cohort analysis Cohort Studies controlled study cytokeratin 19 cytokeratin 19 fragment female Female gender geography Geography glycosylphosphatidylinositol anchored protein GPI-Linked Proteins groups by age human human epididymis protein 4 Humans immunoassay Immunoassay Keratin-19 lung cancer lung neoplasms Lung Neoplasms lung tumor major clinical study male Male middle aged Middle Aged multicenter study neuron specific enolase NSMCE1 protein, human observational study patient care peptide fragment Peptide Fragments population structure practice guideline procedures progastrin releasing peptide progastrin-releasing peptide pro-gastrin-releasing peptide (31-98) prognosis Prognosis protein blood level recombinant protein Recombinant Proteins reference value Reference Values sample size serine proteinase inhibitor Serpins sex factor Sex Factors squamous cell carcinoma antigen squamous cell carcinoma-related antigen tumor antigen tumor biomarkers tumor marker very elderly WAP four-disulfide core domain protein 2 WAP Four-Disulfide Core Domain Protein 2 WFDC2 protein, human young adult Young Adult
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Age-stratified and gender-specific reference intervals of six tumor markers panel of lung cancer: A geographic-based multicenter study in China

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