Expression of long non-coding RNA LUCAT1 in patients with chronic obstructive pulmonary disease and its potential functions in regulating cigarette smoke extract-induced 16HBE cell proliferation and apoptosis

Expression of long non-coding RNA LUCAT1 in patients with chronic obstructive pulmonary disease and its potential functions in regulating cigarette smoke extract-induced 16HBE cell proliferation and apoptosis

Background: Chronic obstructive pulmonary disease (COPD), characterized by persistent airflow limitation, was a disease mediated by a combination of inflammatory factors, immune cells, and immune mediators. COPD was an inflammatory and autoimmune disease involving T-lymphocytes triggered by cigarett...

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Bibliographic Details
Main Authors: Cheng, J. (Author), Lin, C. (Author), Lu, J. (Author), Qian, X. (Author), Yang, T. (Author), Zhao, S. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
16HBE
16HBE14o- cell line
aged
Aged
apoptosis
Apoptosis
Article
Base Sequence
beta catenin
biological marker
Biomarkers
cancer growth
cell line
Cell Line
cell proliferation
Cell Proliferation
chronic obstructive lung disease
chronic obstructive pulmonary disease
cigarette smoke
cigarette smoke extract
cohort analysis
correlational study
demography
disease exacerbation
Disease Progression
disease surveillance
down regulation
Down-Regulation
enzyme linked immunosorbent assay
female
Female
gene expression
gene silencing
Gene Silencing
gene targeting
genetics
human
human cell
Humans
in vitro study
interleukin 1beta
interleukin 6
lncRNA LUCAT1
long non-coding RNA LUCAT1, human
long untranslated RNA
long untranslated RNA LUCAT1
luciferase assay
lung function
major clinical study
male
Male
metabolism
microRNA
microRNA 181a 5p
MicroRNAs
miR-181a-5p
MIrn181 microRNA, human
nucleotide sequence
pathogenesis
pathology
protein expression
Pulmonary Disease, Chronic Obstructive
real time polymerase chain reaction
RNA, Long Noncoding
smoking
Smoking
tumor necrosis factor
unclassified drug
upregulation
Up-Regulation
Western blotting
Wnt protein
Wnt signaling
Wnt Signaling Pathway
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