Knockdown of lncRNA MALAT1 ameliorates acute kidney injury by mediating the miR-204/APOL1 pathway

Knockdown of lncRNA MALAT1 ameliorates acute kidney injury by mediating the miR-204/APOL1 pathway

Background: Acute kidney injury (AKI) was characterized by loss of renal function, associated with chronic kidney disease, end-stage renal disease, and length of hospital stay. Long non-coding RNAs (lncRNAs) participated in AKI development and progression. Here, we aimed to investigate the roles and...

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Bibliographic Details
Main Authors: Jiang, H.-T (Author), Lu, H.-Y (Author), Wang, G.-Y (Author), Zhao, J.-W (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
acute kidney failure
acute kidney injury
Acute Kidney Injury
adult
Adult
APOL1
APOL1 protein, human
apolipoprotein L1
Apolipoprotein L1
apoptosis
Article
blood
blood level
case control study
Case-Control Studies
cell hypoxia
Cell Hypoxia
cell line
Cell Line
controlled study
diagnostic test accuracy study
diagnostic value
disease exacerbation
female
Female
gene expression regulation
Gene Expression Regulation
gene knockdown
Gene Knockdown Techniques
gene silencing
genetics
HK-2 [Human kidney] cell line
human
human cell
Humans
hypoxia
immunoglobulin enhancer binding protein
in vitro study
inflammation
interleukin 1beta
interleukin 6
kidney function test
Kidney Function Tests
lncRNA MALAT1
long untranslated RNA
major clinical study
MALAT1
MALAT1 long non-coding RNA, human
male
Male
metabolism
microRNA
MicroRNAs
middle aged
Middle Aged
miR 204
miR-204
MIRN204 microRNA, human
NF kB signaling
NF-kappa B
pathology
protein expression
RNA, Long Noncoding
sensitivity and specificity
tumor necrosis factor
unclassified drug
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