Preliminary exploration on the serum biomarkers of bloodstream infection with carbapenem-resistant Klebsiella pneumoniae based on mass spectrometry

Preliminary exploration on the serum biomarkers of bloodstream infection with carbapenem-resistant Klebsiella pneumoniae based on mass spectrometry

Background: Carbapenem-resistant K. pneumoniae (CRKP) bloodstream infections (BSI) must be rapidly identified to improve patient survival rates. This study investigated a new mass spectrometry-based method for improving the identification of CRKP BSI and explored potential biomarkers that could diff...

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Bibliographic Details
Main Authors: Bao, J. (Author), Ding, M. (Author), Du, G. (Author), Gu, B. (Author), Guo, L. (Author), Kang, H. (Author), Ma, Y. (Author), Wang, C. (Author), Zhou, Y. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
adolescent
Adolescent
adult
Adult
aged
Aged
Aged, 80 and over
animal
animal cell
animal experiment
animal model
animal tissue
Animals
Anti-Bacterial Agents
antibiotic sensitivity
antiinfective agent
Article
bacterial bloodstream infection
bacterium identification
biological marker
Biomarkers
blood
blood sampling
bloodstream infection
carbapenem
carbapenem derivative
carbapenem resistant Klebsiella pneumoniae
carbapenem-resistant Enterobacteriaceae
Carbapenem-Resistant Enterobacteriaceae
carbapenem-resistant K. pneumoniae
Carbapenems
clinical article
controlled study
diagnostic accuracy
diagnostic test
diagnostic test accuracy study
diagnostic value
drug effect
Drug Resistance, Multiple, Bacterial
early diagnosis
Early Diagnosis
Enterobacteriaceae infection
Enterobacteriaceae Infections
female
Female
fibrinogen
fibrinogen alpha
human
human cell
Humans
imipenem
Institute for Cancer Research mouse
inter alpha trypsin inhibitor
isolation and purification
Klebsiella pneumoniae infection
MALDI-TOF MS
male
Male
mass spectrometry
Mass Spectrometry
matrix assisted laser desorption ionization time of flight mass spectrometry
meropenem
Mice
Mice, Inbred ICR
microbiology
middle aged
Middle Aged
mouse
multidrug resistance
multidrug resistant Klebsiella pneumoniae
nonhuman
peptide
peptide blood level
peptide derivative
peptide fragment
Peptide Fragments
plasma protein
polypeptide
procedures
protein blood level
protein determination
protein expression
sensitivity and specificity
sepsis
Sepsis
serum amyloid A
unclassified drug
very elderly
young adult
Young Adult
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