CTR9-mediated JAK2/STAT3 pathway promotes the proliferation, migration, and invasion of human glioma cells

Background: CTR9 (Cln three requiring 9) has been reported to be implicated in protein modification and oncogenesis of several human cancers. However, the protein expression and mechanism of CTR9 in glioma progression remain unclear. Methods: We analyzed mRNA expression of CTR9 and CTR9-related surv...

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Bibliographic Details
Main Authors:	Chen, J. (Author), He, G. (Author), Xu, Y. (Author), Zhang, Y. (Author)
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2021
Subjects:	analysis of variance apoptosis Apoptosis Article Biomarkers, Tumor Brain Neoplasms brain tumor cancer prognosis case control study Case-Control Studies cell function cell invasion cell line cell migration cell motion Cell Movement cell proliferation Cell Proliferation controlled study CTR9 CTR9 gene CTR9 protein CTR9 protein, human disease marker embryo gene gene expression gene expression level gene expression regulation Gene Expression Regulation, Neoplastic gene knockdown gene overexpression gene silencing genetic database genetics glioma Glioma glioma cell human human cell human tissue Humans JAK2 JAK2 protein, human JAK2-STAT3 signaling JAK-STAT signaling Janus kinase 2 Janus Kinase 2 messenger RNA metabolism Neoplasm Invasiveness pathology pathway phosphoprotein Phosphoproteins prognosis Prognosis protein function STAT3 STAT3 protein STAT3 protein, human STAT3 Transcription Factor Student t test survival survival rate Survival Rate transcription factor Transcription Factors tumor cell culture Tumor Cells, Cultured tumor invasion tumor marker U-251MG cell line U87 cell line unclassified drug Western blotting
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CTR9-mediated JAK2/STAT3 pathway promotes the proliferation, migration, and invasion of human glioma cells

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