Integrative analysis of hub genes and key pathway in two subtypes of diffuse large B-cell lymphoma by bioinformatics and basic experiments

Integrative analysis of hub genes and key pathway in two subtypes of diffuse large B-cell lymphoma by bioinformatics and basic experiments

Background: The germinal center B-cell (GCB) and activated B-cell (ABC) subtypes of diffuse large B-cell lymphoma (DLBCL) have a significant difference in prognosis. This study aimed to identify potential hub genes, and key pathways involved in them. Methods: Databases including Gene Expression Omni...

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Bibliographic Details
Main Authors: Charwudzi, A. (Author), Hu, L. (Author), Li, Q. (Author), Meng, Y. (Author), Zhai, Z. (Author), Zhu, W. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
Article
bioinformatics
biology
cancer prognosis
carcinogenesis
CCND2 gene
CD44 gene
cell cycle
classification
cohort analysis
Computational Biology
Databases, Genetic
differential gene expression
diffuse large B cell lymphoma
diffuse large B-cell lymphoma
expression profiling data
gene
gene expression
gene ontology
gene overexpression
gene regulatory network
Gene Regulatory Networks
genetic analysis
genetic database
genetics
Hermes antigen
hub genes
human
human cell
Humans
IL 10 gene
interleukin 10
Lymphoma, Large B-Cell, Diffuse
metabolism
mortality
procedures
prognosis
Prognosis
protein analysis
Protein Interaction Maps
real time polymerase chain reaction
signal transduction
Signal Transduction
signaling pathway
transcriptome
Transcriptome
Western blotting
Wnt protein
Wnt signaling
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