Dihydropyrimidine dehydrogenase (DPYD) gene c.1627A>G A/G and G/G genotypes are risk factors for lymph node metastasis and distant metastasis of colorectal cancer

Dihydropyrimidine dehydrogenase (DPYD) gene c.1627A>G A/G and G/G genotypes are risk factors for lymph node metastasis and distant metastasis of colorectal cancer

Background: Dihydropyrimidine dehydrogenase (DPD) acts as the key enzyme catabolizing pyrimidines, and may affect the tumor progression. DPYD gene mutations affect DPD activity. The relationship between DPYD IVS14+1G>A, c.1627A>G, c.85T>C and lymph node metastasis (LNM) and distant metastas...

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Bibliographic Details
Main Authors: Huang, Q. (Author), Li, J. (Author), Wu, H. (Author), Yu, Z. (Author), Zeng, J. (Author), Zhong, Z. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
adult
Adult
aged
Aged
Aged, 80 and over
Article
blood level
CA 242 antigen
cancer prognosis
cancer staging
carcinoembryonic antigen
clinical feature
colorectal cancer
Colorectal Neoplasms
colorectal tumor
dihydropyrimidine dehydrogenase
Dihydrouracil Dehydrogenase (NADP)
distant metastasis
DPYD
DPYD gene
female
Female
genetic association
genetic predisposition
Genetic Predisposition to Disease
genetics
genotype
human
human tissue
Humans
lymph node metastasis
Lymphatic Metastasis
major clinical study
male
Male
middle aged
Middle Aged
mutation rate
pathology
polymerase chain reaction
Polymorphism, Single Nucleotide
retrospective study
risk factor
Risk Factors
Sanger sequencing
single nucleotide polymorphism
very elderly
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