miR-3146 induces neutrophil extracellular traps to aggravate gout flare

miR-3146 induces neutrophil extracellular traps to aggravate gout flare

Background: Gout is an inflammatory arthritis and is characterized by the accumulation of deposited monosodium urate (MSU) crystals in the joints. miRNAs may act as key regulators of gout pathogenesis. The aim of our study was to explore the underlying role and molecular mechanism of miR-3146 in the...

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Bibliographic Details
Main Authors: Feng, F. (Author), Li, X. (Author), Shan, L. (Author), Yang, D. (Author), Zhu, D. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
adult
Adult
aged
Aged
animal
animal experiment
Animals
antagomir
Article
clinical article
controlled study
disease model
Disease Models, Animal
extracellular trap
Extracellular Traps
genetics
gout
Gout
histopathology
human
human cell
Humans
hyperuricemia
in vivo study
luciferase assay
male
Male
metabolism
microRNA
microRNA 1
microRNA 3146
MicroRNAs
middle aged
Middle Aged
miR-3146
molecular mechanics
neutrophil extracellular traps
nonhuman
oxidative stress
pathogenesis
pathology
protein synthesis
protein targeting
rat
Rats
Rats, Sprague-Dawley
reactive oxygen metabolite
real time reverse transcription polymerase chain reaction
SIRT1
sirtuin 1
Sprague Dawley rat
unclassified drug
urate
Western blotting
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