miR-423-3p activates FAK signaling pathway to drive EMT process and tumor growth in lung adenocarcinoma through targeting CYBRD1

miR-423-3p activates FAK signaling pathway to drive EMT process and tumor growth in lung adenocarcinoma through targeting CYBRD1

Background: Lung adenocarcinoma (LUAD) is a malignant tumor with a high fatality rate and poor overall survival, while molecular targets diagnosing and alleviating lung cancer remain inadequate. Methods: In this article, we highlighted the upregulation of microRNA-423-3p (miR-423-3p) in LUAD, especi...

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Bibliographic Details
Main Authors: Bai, X. (Author), Feng, Y. (Author), Huang, W. (Author), Ma, J. (Author), Qi, Q. (Author), Sun, X. (Author), Wang, C. (Author), Zhang, L. (Author), Zhang, Q. (Author), Zhu, C. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
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Adenocarcinoma of Lung
adult
Adult
aged
Aged
aging
animal
animal experiment
animal model
animal tissue
Animals
Article
Bagg albino mouse
cancer prognosis
cancer staging
cell adhesion
cell invasion
Cell Line, Tumor
cell proliferation
Cell Proliferation
controlled study
CYBRD1
CYBRD1 protein, human
cytochrome b
Cytochrome b Group
drug screening
enzyme activation
epithelial mesenchymal transition
epithelial–mesenchymal transition
Epithelial-Mesenchymal Transition
FAK/Paxillin
focal adhesion kinase
focal adhesion kinase 1
Focal Adhesion Kinase 1
gene expression regulation
Gene Expression Regulation, Neoplastic
gene overexpression
genetics
human
human cell
Humans
in vivo study
invasion
lung adenocarcinoma
Lung Neoplasms
lung tumor
metabolism
Mice, Inbred BALB C
microRNA
microRNA 423 3p
MicroRNAs
middle aged
Middle Aged
miR-423-3p
MIRN423 microRNA, human
mortality
mouse
nonhuman
oxidoreductase
Oxidoreductases
pathology
physiology
protein cytochrome B reductase 1
protein depletion
PTK2 protein, human
signal transduction
Signal Transduction
smoking
tumor cell line
tumor growth
unclassified drug
upregulation
Xenograft Model Antitumor Assays
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