Dysregulated ferroptosis-related genes indicate potential clinical benefits for anti–PD-1/PD-L1 immunotherapy in lung adenocarcinoma

Background: Ferroptosis is an iron-dependent programmed cell death mechanism that influences the development of malignancy. Lung adenocarcinoma (LUAD) is the most common type of lung cancer with no known cure. Anti–PD-1/PD-L immunotherapy is effective for patients with partial LUAD. Therefore, there...

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Bibliographic Details
Main Authors:	Chen, Y. (Author), Li, T. (Author), Zhang, X. (Author), Zhou, M. (Author)
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2021
Subjects:	Adenocarcinoma of Lung adult aged Aged aneuploidy anti-PD-1/PD-L1 immunotherapy apoptosis area under the curve Article B7-H1 Antigen cancer immunotherapy cancer prognosis cancer survival carcinogenesis CD274 protein, human CD44 protein, human decision model disease free survival drug effect female Female ferroptosis Ferroptosis gene expression gene expression regulation Gene Expression Regulation, Neoplastic gene mutation genetic analysis genetic association genetics glucose 6 phosphate dehydrogenase Glucosephosphate Dehydrogenase Hermes antigen human Humans Hyaluronan Receptors hyaluronic acid binding protein immune checkpoint inhibitor Immune Checkpoint Inhibitors immune heterogeneity immunoreactivity immunotherapy Immunotherapy individualization kelch like ECH associated protein 1 lung adenocarcinoma Lung Neoplasms lung tumor major clinical study male Male metabolism middle aged Middle Aged mutation Mutation overall survival pathology PDCD1 protein, human pharmacology prediction procedures prognosis Prognosis Programmed Cell Death 1 Receptor programmed death 1 ligand 1 programmed death 1 ligand 1 inhibitor programmed death 1 receptor protein p53 radiation response rank sum test receiver operating characteristic recursive partitioning regression analysis transcription factor ZEB1 treatment outcome tumor immunity unclassified drug ZEB1 protein, human Zinc Finger E-box-Binding Homeobox 1
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Dysregulated ferroptosis-related genes indicate potential clinical benefits for anti–PD-1/PD-L1 immunotherapy in lung adenocarcinoma

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