Resolvin D2 attenuates chronic pain–induced depression-like behavior in mice

Resolvin D2 attenuates chronic pain–induced depression-like behavior in mice

Aim: We previously demonstrated that intracerebroventricular injection of resolvin D2 (RvD2), a bioactive lipid mediator derived from docosahexaenoic acid, ameliorated depression-like behavior in lipopolysaccharide-induced and chronic mild stress–induced mouse models of depression. In the present st...

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Bibliographic Details
Main Authors: Deyama, S. (Author), Hitora-Imamura, N. (Author), Minami, M. (Author), Suzuki, H. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
animal
animal experiment
animal model
Animals
antidepressant
antidepressant activity
antidepressant agent
Antidepressive Agents
Article
chloral hydrate
chronic pain
Chronic Pain
chronic stress
controlled study
depression
Depression
docosahexaenoic acid
Docosahexaenoic Acids
fatty acid derivative
immobility time
isoflurane
locomotion
male
Mice
mouse
n-3 polyunsaturated fatty acid
neuropathic pain
nonhuman
open field test
pain
pain threshold
paw withdrawal threshold
peroneus nerve
resolvin
resolvin D2
spared nerve injury
tail suspension test
tibial nerve
total distance traveled
unclassified drug
von Frey test
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