The dopamine D2 agonist quinpirole impairs frontal mismatch responses to sound frequency deviations in freely moving rats

The dopamine D2 agonist quinpirole impairs frontal mismatch responses to sound frequency deviations in freely moving rats

Aim: A reduced mismatch negativity (MMN) response is a promising electrophysiological endophenotype of schizophrenia that reflects neurocognitive impairment. Dopamine dysfunction is associated with symptoms of schizophrenia. However, whether the dopamine system is involved in MMN impairment remains...

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Bibliographic Details
Main Authors: Inaba, H. (Author), Kida, S. (Author), Namba, H. (Author), Nawa, H. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
Acoustic Stimulation
animal
animal experiment
animal model
Animals
Article
auditory cortex
auditory evoked potential
auditory stimulation
bregma
butorphanol
cefmetazole
cerebellum
clinical assessment
controlled study
dopamine
Dopamine
dopamine 2 receptor
Dopamine Agonists
dopamine receptor stimulating agent
drug effect
electrocorticography
electroencephalography
Electroencephalography
event related potential
Evoked Potentials, Auditory
frontal cortex
male
medetomidine
midazolam
middle-latency response
mismatch negativity
nerve cell
nonhuman
primary auditory cortex
quinpirole
Quinpirole
rat
Rats
schizophrenia
sound analysis
sound pressure
temporalis muscle
waveform
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