Allostery-driven changes in dynamics regulate the activation of bacterial copper transcription factor

Allostery-driven changes in dynamics regulate the activation of bacterial copper transcription factor

Metalloregulators bind and respond to metal ions by regulating the transcription of metal homeostasis genes. Copper efflux regulator (CueR) is a copper-responsive metalloregulator that is found in numerous Gram-negative bacteria. Upon Cu(I) coordination, CueR initiates transcription by bending the b...

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Bibliographic Details
Main Authors: Gevorkyan-Airapetov, L. (Author), Hofmann, L. (Author), Mandato, A. (Author), Ruthstein, S. (Author), Saxena, S. (Author), Shenberger, Y. (Author), Singewald, K. (Author), Yakobov, I. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2022
Subjects:
copper homeostasis
CueR
EPR
metalloregulator
protein–DNA interaction
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