Dimeric assembly of human Suv3 helicase promotes its RNA unwinding function in mitochondrial RNA degradosome for RNA decay

Dimeric assembly of human Suv3 helicase promotes its RNA unwinding function in mitochondrial RNA degradosome for RNA decay

Human Suv3 is a unique homodimeric helicase that constitutes the major component of the mitochondrial degradosome to work cooperatively with exoribonuclease PNPase for efficient RNA decay. However, the molecular mechanism of how Suv3 is assembled into a homodimer to unwind RNA remains elusive. Here,...

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Bibliographic Details
Main Authors: Agrawal, S. (Author), Golzarroshan, B. (Author), Jain, M. (Author), Lin, C.-L (Author), Tang, W.-H (Author), Wu, C.-J (Author), Yuan, H.S (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2022
Subjects:
mitochondrial homeostasis
mitochondrial RNA degradation
RNA helicase
RNA metabolism
RNA turnover
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