Improving sample size recalculation in adaptive clinical trials by resampling
Sample size calculations in clinical trials need to be based on profound parameter assumptions. Wrong parameter choices may lead to too small or too high sample sizes and can have severe ethical and economical consequences. Adaptive group sequential study designs are one solution to deal with planni...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
John Wiley and Sons Ltd
2021
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| Subjects: | |
| Online Access: | View Fulltext in Publisher |