RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53

RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53

Glycolysis is essential to support cancer cell proliferation, even in the presence of oxygen. The transcriptional co-regulator RIP140 represses the activity of transcription factors that drive cell proliferation and metabolism and plays a role in mammary tumorigenesis. Here we use cell proliferation...

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Bibliographic Details
Main Authors: Bonnet, S. (Author), Cavaillès, V. (Author), Fritsch, S. (Author), Gitenay, D. (Author), Győrffy, B. (Author), Jacquier, V. (Author), Jalaguier, S. (Author), Linares, L.K (Author), Teyssier, C. (Author)
Format: Article
Language:English
Published: Springer Science and Business Media Deutschland GmbH 2022
Subjects:
basic helix loop helix transcription factor
Basic Helix-Loop-Helix Transcription Factors
Breast cancer
Breast Neoplasms
breast tumor
Cancer cell metabolism
cell proliferation
Cell Proliferation
female
Female
genetics
glucose transporter 3
Glucose Transporter Type 3
GLUT3
glycolysis
Glycolysis
HIF
human
Humans
hypoxia
Hypoxia
metabolism
p53
pathology
protein p53
RIP140
Transcription factors
Tumor Suppressor Protein p53
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