New insights into the molecular mechanisms of ROR1, ROR2, and PTK7 signaling from the proteomics and pharmacological modulation of ROR1 interactome

New insights into the molecular mechanisms of ROR1, ROR2, and PTK7 signaling from the proteomics and pharmacological modulation of ROR1 interactome

ROR1, ROR2, and PTK7 are Wnt ligand-binding members of the receptor tyrosine kinase family. Despite their lack of catalytic activity, these receptors regulate skeletal, cardiorespiratory, and neurological development during embryonic and fetal stages. However, their overexpression in adult tissue is...

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Bibliographic Details
Main Authors: Dini, A. (Author), Karvonen, H. (Author), Niininen, W. (Author), Piki, E. (Author), Raivola, J. (Author), Salokas, K. (Author), Ungureanu, D. (Author), Varjosalo, M. (Author)
Format: Article
Language:English
Published: Springer Science and Business Media Deutschland GmbH 2022
Subjects:
CETSA
GZD824
Kinase inhibitors
PTK7
Receptor pseudokinases
ROR1
ROR2
TSA
Wnt signaling
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