Synthesis of damnacanthal, a naturally occurring 9,10-anthraquinone and its analogues, and its biological evaluation against five cancer cell lines

Synthesis of damnacanthal, a naturally occurring 9,10-anthraquinone and its analogues, and its biological evaluation against five cancer cell lines

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Damnacanthal and nordamnacanthal, two naturally occurring 9,10-anthraquinones, and their analogues were synthesized. Cytotoxic activity against five cancer cell lines was evaluated using MTT assay. 2-Bromomethyl-1,3-dimethoxyanthraquinone was found to display the highest activity against all cell li...

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Bibliographic Details
Main Authors: Abas, F. (Author), Hui, L.S (Author), Lajis, N.H (Author), Lam, K.W (Author), Saha, K. (Author), Sazali Hamzah, A. (Author), Stanslas, J. (Author)
Format: Article
Language:English
Subjects:
2 bromomethyl 1,3 dimethoxyanthraquinone
3 acetoxy 2 bromomethyl 1 methoxyanthraquinone
4 bromo 2 formyl 3 hydroxy 1 methoxyanthraquinone
alizarin
aluminum chloride
anthraquinone derivative
Anthraquinones
antioxidant
antioxidant activity
Antioxidant activity
article
benzene
breast cancer
bromination
cancer cell culture
cell assay
Cytotoxicity
damnacanthal
demethylation
drug cytotoxicity
drug synthesis
human
human cell
IC 50
lipid peroxidation
lipophilicity
lung cancer
nordamnacanthal
phthalic anhydride
physical chemistry
prostate cancer
structure activity relation
Synthesis
thiobarbituric acid
thiocyanate
unclassified drug
uterus sarcoma
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