Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart

Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart

Cardiac contractile strength is recognised as being highly pH-sensitive, but less is known about the influence of pH on cardiac gene expression, which may become relevant in response to changes in myocardial metabolism or vascularization during development or disease. We sought evidence for pH-respo...

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Bibliographic Details
Main Authors: Andreev, O.A (Author), Carr, C.A (Author), Chung, Y.J (Author), Crump, N.T (Author), Curtis, M.K (Author), Fournier, M. (Author), Gunadasa-Rohling, M. (Author), Hulikova, A. (Author), Loonat, A.A (Author), Milne, T.A (Author), Moshnikova, A. (Author), Park, K.C (Author), Reshetnyak, Y.K (Author), Riley, P.R (Author), Smart, N. (Author), Swietach, P. (Author), Trafford, A.W (Author), Wilson, A. (Author)
Format: Article
Language:English
Published: Springer Science and Business Media Deutschland GmbH 2022
Subjects:
acidity
Acidity
adaptor protein
adult
animal
animal cell
animal experiment
Animals
Article
cardiac muscle
cardiac muscle cell
Cardiomyocyte
cell culture
cell nucleus
Cell Nucleus
cell nucleus membrane
cell pH
chromatin immunoprecipitation
contractile protein
Contraction
controlled study
CRIP2
cysteine rich intestinal protein 2
cysteine rich intestinal protein 2 gene
differential gene expression
down regulation
enzyme activity
epigenetics
gene
gene expression
Gene Expression
gene identification
genetic transcription
heart
heart contraction
heart function
heart muscle contractile force
histone acetyltransferase PCAF
histone H3
immunoreactivity
male
mammal
Mammals
metabolism
mouse
muscle contraction
Myocardial Contraction
myocardin
Myocardium
Myocytes, Cardiac
newborn
nonhuman
Nucleus
peptides and proteins
pH low insertion peptide
promoter region
protein acetylation
proteomics
rat
sodium proton exchange protein
transcription regulation
transcriptomics
unclassified drug
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