Mechanical ventilation-induced alterations of intracellular surfactant pool and blood–gas barrier in healthy and pre-injured lungs

Mechanical ventilation-induced alterations of intracellular surfactant pool and blood–gas barrier in healthy and pre-injured lungs

Mechanical ventilation triggers the manifestation of lung injury and pre-injured lungs are more susceptible. Ventilation-induced abnormalities of alveolar surfactant are involved in injury progression. The effects of mechanical ventilation on the surfactant system might be different in healthy compa...

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Bibliographic Details
Main Authors: Albert, K. (Author), Knudsen, L. (Author), Krischer, J.-M (Author), Lopez-Rodriguez, E. (Author), Pfaffenroth, A. (Author), Ruppert, C. (Author), Smith, B.J (Author)
Format: Article
Language:English
Published: Springer Science and Business Media Deutschland GmbH 2021
Subjects:
adult
Alveolar epithelial type II cells
animal
animal experiment
animal model
animal tissue
Animals
Article
artificial ventilation
bleomycin
Bleomycin
blood gas
Blood-Air Barrier
Blood–gas barrier
body weight
cell size
cell volume
controlled study
Fischer 344 rat
Lamellar bodies
lamellar body
lung
Lung
lung alveolus cell type 2
lung disease
Lung Diseases
lung gas exchange
lung homogenate
lung injury
lung surfactant
lung ventilation
male
Male
Mechanical ventilation
metabolism
nonhuman
positive end expiratory pressure ventilation
priority journal
protein expression
Pulmonary Surfactants
rat
Rats
Rats, Inbred F344
Respiration, Artificial
stereology
Stereology
Surfactant
tidal volume
ultrastructure
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