The calcium-activated chloride channel-associated protein rCLCA2 is expressed throughout rat epidermis, facilitates apoptosis and is downmodulated by UVB

The calcium-activated chloride channel-associated protein rCLCA2 is expressed throughout rat epidermis, facilitates apoptosis and is downmodulated by UVB

The rodent chloride channel regulatory proteins mCLCA2 and its porcine and human homologues pCLCA2 and hCLCA2 are expressed in keratinocytes but their localization and significance in the epidermis have remained elusive. hCLCA2 regulates cancer cell migration, invasion and apoptosis, and its loss pr...

Full description

Bibliographic Details
Main Authors: Bart, G. (Author), Deen, A. (Author), Hämäläinen, L. (Author), Kärkkäinen, E. (Author), Kärnä, R. (Author), Kumlin, T. (Author), Pasonen-Seppänen, S. (Author), Rauhala, L. (Author), Takabe, P. (Author), Tammi, M.I (Author), Tammi, R.H (Author)
Format: Article
Language:English
Published: Springer Science and Business Media Deutschland GmbH 2021
Subjects:
animal
animal cell
animal experiment
animal tissue
Animals
apoptosis
Apoptosis
Article
biosynthesis
caspase 3
caspase 7
cell culture
cell differentiation
cell maturation
Cells, Cultured
chloride channel
Chloride Channels
CLCA2 protein, rat
controlled study
down regulation
Down-Regulation
epidermis
Epidermis
gene silencing
immunohistochemistry
in vitro study
in vivo study
keratinocyte
Keratinocytes
messenger RNA
metabolism
Mice
mouse
mRNA expression level
nonhuman
priority journal
protein
protein expression level
rat
Rats
rCLCA2
REK
rodent chloride channel regulatory protein 2
skin carcinogenesis
ultraviolet B radiation
ultraviolet radiation
Ultraviolet Rays
unclassified drug
UVR
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items