Binding of gephyrin to microtubules is regulated by its phosphorylation at Ser270

Binding of gephyrin to microtubules is regulated by its phosphorylation at Ser270

Gephyrin is a multifunctional scaffolding protein anchoring glycine- and subtypes of GABA type A- receptors at inhibitory postsynaptic membrane specializations by binding to the microtubule (MT) and/or the actin cytoskeleton. However, the conditions under which gephyrin can bind to MTs and its regul...

Full description

Bibliographic Details
Main Authors: Demmig, R. (Author), Kirsch, J. (Author), Kiss, E. (Author), Kuhse, J. (Author), Nawrotzki, R.A (Author), Zhou, L. (Author)
Format: Article
Language:English
Published: Springer Science and Business Media Deutschland GmbH 2021
Subjects:
adult
alanine
animal
animal cell
animal experiment
Animals
Article
binding affinity
binding site
Binding Sites
brain tissue
cell culture
Cells, Cultured
centrifugation
controlled study
gene mutation
gephyrin
Gephyrin
HEK293 cell line
HEK293 Cells
HEK293T cell line
human
Humans
immunoreactivity
in vitro study
liver tissue
male
membrane protein
Membrane Proteins
metabolism
microtubule
Microtubules
nonhuman
oligomerization
phosphorylation
Phosphorylation
polymerization
protein phosphorylation
rat
Rats
regulatory mechanism
sedimentation
serine
Serine
U2OS cell line
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items