Organic dust exposure induces stress response and mitochondrial dysfunction in monocytic cells

Organic dust exposure induces stress response and mitochondrial dysfunction in monocytic cells

Exposure to airborne organic dust (OD), rich in microbial pathogen-associated molecular patterns (PAMPs), is shown to induce lung inflammation. A common manifestation in lung inflammation is altered mitochondrial structure and bioenergetics that regulate mitochondrial ROS (mROS) and feed a vicious c...

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Bibliographic Details
Main Authors: Charavaryamath, C. (Author), Kanthasamy, A.G (Author), Karriker, L.A (Author), Mahadev Bhat, S. (Author), Massey, N. (Author), Shrestha, D. (Author)
Format: Article
Language:English
Published: Springer Science and Business Media Deutschland GmbH 2021
Subjects:
acetophenone derivative
Acetophenones
apocynin
apoptosis
Article
cell culture
cell membrane permeability
cell nucleus
cell organelle
cell protection
cell structure
cell survival
Cell Survival
cell vacuole
cell viability
Cells, Cultured
cellular stress response
controlled study
cytochrome c
cytosol
disorders of mitochondrial functions
DNA damage
drug effect
dust
Dust
dust exposure
environmental exposure
Environmental Exposure
environmental monitoring
Environmental Monitoring
enzyme release
ethyl pyruvate
Ethyl pyruvate
high mobility group B1 protein
human
human cell
Humans
interleukin 1beta converting enzyme
metabolism
mitoapocynin
Mitoapocynin
Mitochondria
mitochondrial DNA
Mitochondrial DNA
Mitochondrial dysfunction
mitochondrial membrane
mitochondrial toxicity
mitochondrial transcription factor A
mitochondrion
mitophagy
monocyte
Monocytes
organic dust
Organic dust
oxidative stress
Oxidative Stress
parkin
pathogen associated molecular pattern
phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase
protein expression
pseudopodium
pten induced kinase 1
Pyruvates
pyruvic acid
receptor upregulation
THP-1 cell line
transmission electron microscopy
unclassified drug
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