Senescence and associated blood–brain barrier alterations in vitro

Senescence and associated blood–brain barrier alterations in vitro

Progressive deterioration of the central nervous system (CNS) is commonly associated with aging. An important component of the neurovasculature is the blood–brain barrier (BBB), majorly made up of endothelial cells joined together by intercellular junctions. The relationship between senescence and c...

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Bibliographic Details
Main Authors: Burek, M. (Author), Förster, C.Y (Author), Hagemann, C. (Author), Löhr, M. (Author), Nagai, M. (Author), Salvador, E. (Author)
Format: Article
Language:English
Published: Springer Science and Business Media Deutschland GmbH 2021
Subjects:
Aging
animal
animal cell
Animals
Article
astrocyte
beta galactosidase
biological model
blood brain barrier
Blood–brain barrier
Blood-Brain Barrier
cell aging
cell culture
cell membrane permeability
Cells, Cultured
Cellular Senescence
CNS diseases
cytology
DNA
DNA damage response
DNA synthesis
Endothelial Cells
endothelium cell
immunofluorescence assay
In vitro model
in vitro study
Ki 67 antigen
metabolism
Mice
Models, Biological
mouse
nonhuman
oxidative stress
pericyte
phenotype
protein expression
Senescence
Western blotting
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