Selective involution of thymic medulla by cyclosporine A with a decrease of mature thymic epithelia, XCR1+ dendritic cells, and epithelium-free areas containing Foxp3+ thymic regulatory T cells

Selective involution of thymic medulla by cyclosporine A with a decrease of mature thymic epithelia, XCR1+ dendritic cells, and epithelium-free areas containing Foxp3+ thymic regulatory T cells

Immunosuppressive drugs such as cyclosporine A (CSA) can disrupt thymic structure and functions, ultimately inducing syngeneic/autologous graft-versus-host disease together with involuted medullas. To elucidate the effects of CSA on the thymus more precisely, we analyzed the effects of CSA on the th...

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Bibliographic Details
Main Authors: Kitazawa, Y. (Author), Matsuno, K. (Author), Sawanobori, Y. (Author), Tokuda, N. (Author), Ueta, H. (Author)
Format: Article
Language:English
Published: Springer Science and Business Media Deutschland GmbH 2021
Subjects:
animal
animal experiment
animal model
Animals
Article
chemokine receptor
controlled study
cyclosporine
Cyclosporine
dendritic cell
Dendritic cells
Dendritic Cells
down regulation
drug effect
Epithelial Cells
epithelium cell
fluorescence imaging
forkhead transcription factor
Forkhead Transcription Factors
Foxp3 protein, rat
graft versus host reaction
immunohistochemistry
Immunohistochemistry
immunosuppressive agent
Immunosuppressive Agents
Immunosuppressive drug
immunosuppressive treatment
in vivo study
Injections, Subcutaneous
Lewis rat
major histocompatibility antigen class 2
major histocompatibility complex
male
Male
metabolism
nonhuman
Optical Imaging
pathology
peptides and proteins
phenotype
protein xcr1
rat
Rats
Rats, Inbred Lew
Receptors, Chemokine
Regulatory T cells
regulatory T lymphocyte
subcutaneous drug administration
T lymphocyte
Thymic epithelial cells
thymic medulla
Thymic structure
thymocyte
Thymocytes
thymus
Thymus
Thymus Gland
T-Lymphocytes, Regulatory
transcription factor FOXP3
unclassified drug
XCR1 protein, rat
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