Overexpression of the nucleoporin Nup88 stimulates migration and invasion of HeLa cells

Overexpression of the nucleoporin Nup88 stimulates migration and invasion of HeLa cells

Elevated expression of the nucleoporin Nup88, a constituent of the nuclear pore complex, is seen in various types of malignant tumors, but whether this overexpression contributes to the malignant phenotype has yet to be determined. Here, we investigated the effect of the overexpression of Nup88 on t...

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Bibliographic Details
Main Authors: Higashi, K. (Author), Kuniyasu, A. (Author), Makise, M. (Author), Mashiki, Y. (Author), Shiraishi, R. (Author), Shutoku, Y. (Author), Uchimura, R. (Author)
Format: Article
Language:English
Published: Springer Science and Business Media Deutschland GmbH 2021
Subjects:
Article
cancer cell culture
cell culture
cell invasion
cell migration
cell motion
Cell Movement
Cells, Cultured
cervical cancer cell line
DNA microarray
epithelial mesenchymal transition
gene overexpression
genetic transfection
genetics
HeLa cell line
HeLa cells
HeLa Cells
human
human cell
Humans
immunoblotting
immunoglobulin enhancer binding protein
in vitro study
intermediate filament protein
Invasion
live cell imaging
macrophage elastase
malignant transformation
metabolism
Migration
MMP-12
NF-κB
nuclear pore complex
Nuclear Pore Complex Proteins
nucleoporin
nucleoporin 88
Nup88
NUP88 protein, human
phenotype
plasmid
prostate cancer cell line
protein expression
radioimmunoprecipitation
real time polymerase chain reaction
RNA interference
unclassified drug
upregulation
uvomorulin
vimentin
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