Initial mechanical conditions within an optimized bone scaffold do not ensure bone regeneration – an in silico analysis

Large bone defects remain a clinical challenge because they do not heal spontaneously. 3-D printed scaffolds are a promising treatment option for such critical defects. Recent scaffold design strategies have made use of computer modelling techniques to optimize scaffold design. In particular, scaffo...

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Bibliographic Details
Main Authors:	Checa, S. (Author), Duda, G.N (Author), Perier-Metz, C. (Author)
Format:	Article
Language:	English
Published:	Springer Science and Business Media Deutschland GmbH 2021
Subjects:	Article Biomechanical Phenomena biomechanics bone Bone and Bones bone development bone regeneration Bone regeneration Bone Regeneration Bone scaffold Bone tissue formation bone volume fraction cell infiltration Computational mechano-biology computer model Computer modelling computer simulation Computer Simulation controlled study data analysis software Defects elasticity Elasticity equipment design Failure (mechanical) fibrocartilage finite element analysis Finite Element Analysis fracture healing geometry human Humans Linear Models Mechanical failures Mechanical stimulation Mechanical stimulus Mechanical strain mechanical stress ossification Osteogenesis physiology Poisson distribution Poisson Distribution pore volume Pore volume fractions porosity Porosity Printing, Three-Dimensional procedures regeneration Regeneration Regeneration process Scaffold design optimization Scaffolds (biology) software Software statistical model Stress, Mechanical Surgery three dimensional printing tissue distribution tissue engineering Tissue Engineering Tissue regeneration tissue scaffold Tissue Scaffolds wound healing Wound Healing Young modulus
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Initial mechanical conditions within an optimized bone scaffold do not ensure bone regeneration – an in silico analysis

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